How ChatGPT diagnosed my rare disease

May 10, 2024
5 minute read

This will be very personal, but I wanted to share this with you.

My grandfather used to take me to fishing. We would wake up at 5am, pack all the fishing gear and go out of town to catch some carps.

On some days we would catch some, on others we would go home empty handed. But one thing was always a constant companion: mosquitoes. You can’t be lakeside and not get bitten by mosquitoes.

(Unless of course you’ve won the genetic lottery - like my wife, Eszti.
Mosquitoes seem to avoid her, which is unfathomable for me.)

So there were the three of us fishing. Little me, my grandpa and the itching. Quite the trio.

The Itching

15 years later I has living in my rental studio in Budapest. It was a hot summer evening and I got out of the shower. I noticed a weird tingling feeling in my arms. Then the tingling became itching. Then it started to spread to all my extremities, then my entire body.

I didn’t know what was happening but I got scared.

“Do I have an allergic reaction? Is it the shampoo? Something about the towel? No signs of visible symptoms on my body. What’s happening?” - the thoughts were racing in my head.

The itching progressed to become so bad I had to sit down as I was completely occupied with it. It was gruelling. I remembered my grandfather from our fishing trips who never seemed to be bothered by it. But why?

I didn’t know at the time, but that summer evening in 2013 was the first day of the rest of my life. Itching returned almost every day since. Sometimes it was annoying, sometimes it was torture. It usually lasted for about an hour. To this day, it just…happens. Out of the blue.

One day when I visited my grandfather I told him:

“Grandpa, do you remember our fishing trips and how I was always bothered by mosquitoes?”
“Yes I do.” - he said, smiling.
“But you weren’t. You were fine. I even remember asking if they were biting you and you said yes. Why are you not bothered by the itching?” - I asked.
“Because I’ve been itching for 60 years. I don’t know why I itch, but I learned to deal with it.”

Okay.

Time stopped.

That was it.

I wasn’t alone.

With a great dash of hope, I went to the doctor. To several, actually. My hopes for a solution diead in a week. Nobody had not even the faintest clue what my issue might have been. Dermatologists said it’s my dry skin. Hepatologists said I had hepatitis. Endocrinologists said I have histamine intolerance. Then we started doing test after test after test and they all came back negative. I even did a DNA test to get my genome data.

On the surface, I was healthy as a cucumber.

But I knew that the moment I step out of the shower, the next hour would be hell.

So I stopped taking showers. I felt dirty and shameful. Some people around me mocked me even. But it was still better than spending an hour in a debilitating itching episode every single day. I even created a system to grade my episodes. 1 would be nothing of notice. 10 would mean crying and shaking for an hour trying to peel off my skin.

The real torture wasn’t that one hour every day. The real torture was that I didn’t know what was happening to my body. It wants to tell me something, but what is it? The doctors have no clue, how could I?

Use AI to make your life better

Then ChatGPT came.

One day, after one of the most debilitating, level 10 attacks, I had an idea. I know ChatGPT pretty well, that’s what I teach. If anyone knows how to use ChatGPT to diagnose a mystery condition, making use of all its features, it’s me.

I wrote my prompt, using the 6 key elements of a prompt. I decided to mimic Dr House (I love that show) and gave my full patient history. Including all the information on my grandfather. Even my DNA data file. I asked ChatGPT to do a differential diagnosis and then recommend a conclusion. (I turned this into a Medical GPT that I shared with our students).

Within 2 minutes, ChatGPT returned an answer

“Based on your medical history and the idiopathic itching, no skin lesions and no history of allergic reactions, you are most likely to have Polycythemia Vera, Essential Thrombocythemia, Histamine Intolerance or Aquagenic Pruritus.”

Sorry, what?!

Then it went on to examine my DNA for a JAK2V617F mutation which - as it explained - is a telltale sign for Polycythemia Vera. It didn’t find anything.

Then ChatGPT comes back and says “Your haemoglobin count is normal, which indicates that even if you do have Polycythemia Vera, it will be rare type. In some cases, JAK2exon12 mutation are present even when a JAK2V617F mutation is not.”

Code Interpreter wrote the code to look for the mutation and…it found it.

It found it

Next week I went to a hematologist and showed the results. Read the full report written by ChatGPT and agreed with the conclusions. He immediately ordered a DNA test, now done at Semmelweis University in Budapest.

3 weeks later, the results came back, confirming the diagnosis.

I have a rare condition called Masked Polycythemia Vera.

(We later did the same test for my grandfather he has the same mutation.)

There are about 10 people in Hungary living with this condition. Me and my grandfather are two of them.

It took 2 minutes to ChatGPT to solve what the best doctors in Budapest and Cambridge couldn’t solve in 10 years.

Now I have meds for it and the doctor helped me create a routine and new habits to deal with it. Itching is still a part of my life, but I haven’t had a major episode in 8 months.

I’m telling you this story because I want you to see the level of AI knowledge that is available to you. Rewriting emails and drafting Linkedin posts are the tip of the iceberg. Rookie stuff. You should be able to use AI to help you solve the big problems in your life. Grow your business. Be happier, healthier. Have more time.

I want to teach you how to become a Prompt Master.
How to solve the big problems in your life, at your work with ease, using AI.

Come join us. I will teach you everything I know.

This knowledge helped me get rid of one of the most debilitating conditions in my life.

It helped Mike save 84% time on creating content for his business.

It helped Janos switch to a new career and take care for his family.

…it will change your life too.

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